Diabetic nephropathy progressed to end-stage renal disease (ESRD) is found in type 1 or type 2 diabetes. Oxidative stress is one of the precipitation factors in diabetic nephropathy. The phenolic derivative maker compound Protocatechuic acid (PCA) shows variety of therapeutic activities. Literature data shows that preclinical evaluation of some activities is still remaining. PCA claims to possess activity against renal complications viz. nephropathy, renal ischemia. The aim of present work was to do screening of PCA against renal complications like diabetic nephropathy by using animal model like alloxan induced diabetic nephropathy in which PCA showed significant activity of inhibition of diabetic nephropathy through inhibition of oxidative stress in experimental animals.
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